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. 2019 Jan 11;9:3099. doi: 10.3389/fimmu.2018.03099

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Copyright © 2019 Hu, Gong, Gu, Geng, Li, Tian, Yang, Zhang, Shao, Liu, Wan, Jia, Yang, Shi and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of AOSD miRNA signature in sepsis patients. Expression levels of (A) miR-142-5p, (B) miR-101-3p, (C) miR-29c-3p, (D) miR-29a-3p, (E) miR-141-3p were analyzed by analyzed by qRT-PCR in an independent set consisting of HC (N = 18), AOSD (N = 25) and sepsis (N = 21) patients. The results of histograms represent the means ± SD, ^*P < 0.01, ^***P < 0.001. (F-H) ROC analysis for individual miRNAs and combined miRNA panel was analyzed by KNN (F), SVM (G) and LR (H) analysis. Logistic regression demonstrated that a linear combination of values for miR-142-5p, miR-101-3p, miR-29c-3p, and miR-141-3p produced the best model to distinguish AOSD patients from sepsis patients.