Table 3.
KEGG pathway analysis of potential prognostic genes associated with HCC
| Pathway | Description | Genes | Gene count | P-value |
|---|---|---|---|---|
| hsa04110 | Cell cycle | CCNB1, CCNE2, CDK1, CDC6, MAD2L1, CDKN2C, TTK, BUB1B, CHEK1, CDC20, MCM2, PTTG1, CCNA2 | 13 | 2.88×10−9 |
| hsa01100 | Metabolic pathways | XDH, CYP3A4, CYP2C9, CYP2C8, ALDOB, FTCD, EPHX2, ADH1A, CPS1, TAT, TK1, PRIM1, ACSM3, CYP4A11, ASPA, G6PD, ACSL1, HMGCS2, AKR1B10, RRM2, BHMT, PON1, CYP4F2, RDH16, AKR1D1, PON3 | 26 | 2.46×10−4 |
| hsa00830 | Retinol metabolism | CYP3A4, CYP4A11, CYP2C9, CYP2C8, ADH1A, RDH16 | 6 | 4.76×10−4 |
| hsa00590 | Arachidonic acid metabolism | CYP4A11, CYP2C9, CYP2C8, EPHX2, CYP4F2 | 5 | 0.003462332 |
| hsa04115 | p53-signaling pathway | CCNB1, CCNE2, CDK1, RRM2, CHEK1 | 5 | 0.0045805 |
| hsa04114 | Oocyte meiosis | CCNE2, CDK1, MAD2L1, AURKA, CDC20, PTTG1 | 6 | 0.004779011 |
| hsa05204 | Chemical carcinogenesis | CYP3A43, CYP3A4, CYP2C9, CYP2C8, ADH1A | 5 | 0.008567382 |
| hsa00982 | Drug metabolism – CYP/CYP450 | CYP3A4, CYP2C9, CYP2C8, ADH1A | 4 | 0.031237741 |
| hsa04610 | Complement and coagulation cascades | C8B, C7, KLKB1, F9 | 4 | 0.032426334 |
| hsa00591 | Linoleic acid metabolism | CYP3A4, CYP2C9, CYP2C8 | 3 | 0.034443742 |
| hsa05166 | HTLV1 infection | MAD2L1, CDKN2C, ETS2, BUB1B, CHEK1, CDC20, PTTG1 | 7 | 0.044372737 |
Abbreviations: HCC, Hepatocellular carcinoma; KEGG, Kyoto Encyclopedia of Genes and Genomes.