Table S1.

Keywords used in systematic review by category

HER2 keywords	HER2 vaccine keywords	Breast cancer keywords	Toxicity keywords	Clinical trials keywordsa
dHER2 HER2HER2/neu “Receptor, ErbB-2”[Mesh] human epidermal growth factor receptor 2 2 her erbb2 neu Gene NEU proto-oncogene neu receptor TKR1	Her2 Vaccine Cancer Vaccines[Mesh] Cancer Vaccines NeuVax Peptide cancer vaccines peptide vaccines Nelipepimut-S GP2 AE37 “E75” E75 HER2-derived peptide vaccine, nelipepimut-S whole cell vaccine CHP-HER2 vaccine [Supplementary Concept]	breast cancer breast neoplasms	Receptor, ErbB-2/toxicity[Mesh] Cancer Vaccines/adverse effects[Mesh] Cancer Vaccines/administration and dosage[Mesh] Toxicity toxicity [Subheading]	(clinical trials OR “clinical trial” OR Clinical Trial[ptyp] OR “phase I” OR “phase II” OR “phase 2” OR “phase 1” OR “phase 1/2” OR “Phase I/II” OR randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR randomised[tiab] OR randomization[tiab] OR randomisation[tiab] OR placebo[tiab] OR drug therapy[sh] OR randomly[tiab] OR trial[tiab] OR groups[tiab]) NOT (animals[mh] NOT humans[mh]) NOT (Editorial[pt] OR Letter[pt] OR Case Reports[pt] OR Comment[pt])

Note:

^aBased on the RCT filter from Cochrane.

Abbreviation: RCT, randomized controlled trial.