Figure 2.

(A) Mitochondrial respiration in intact platelets of patients with BD in depressive episode, patients with MDD, and controls. (B) Mitochondrial respiration in intact platelets of patients with BD in depressive episode, patients with MDD, and controls, normalized to ETS capacity (ETSC).

Notes: PR was measured in diluted platelet-rich plasma; LEAK was measured after the addition of oligomycin; ETSC was determined by titration with uncoupler (FCCP); Rot was measured after the addition of rotenone. Final addition of antimycin A induced ROX, which was subtracted from all other respiratory rates. The mean ± SD is shown. Significantly different mean values are marked by *P<0.05, **P<0.01, and ***P<0.001.

Abbreviations: BD, bipolar disorder; C, complex; ROT, respiration after complex I inhibition; CS, citrate synthase; LEAK, nonphosphorylating respiration; MDD, major depressive disorder; NetPR, net physiological respiration; PR, physiological respiration; ROX, residual oxygen consumption.