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. Author manuscript; available in PMC: 2020 Jan 10.
Published in final edited form as: J Control Release. 2018 Nov 1;293:1–9. doi: 10.1016/j.jconrel.2018.10.033

Scheme 1.

Scheme 1.

(a) Illustration of the preparation of PTX/MTAs from PDEA-b-P(OEGMA-co-PDS) copolymer and the pH-sensitive morphological transition. (b) Schematic illustration of delivery cascade of PTX/MTAs. I) Circulation in the blood vessel; II) Extravasation into tumor; III) PTX/SCTPs dissociating from PTX/MTAs and penetrating into tumor tissue; IV) PTX/SCTPs becoming positively charged as the acidity increase and expediting the cellular uptake; V) Intracellular drug release in respond to a redox stimulus.