Table 1:
(1) Markers of amyloid-beta (Aβ) protein deposition in the brain |
a. low CSF Aβ42 |
b. positive PET amyloid imaging |
(2) Markers of downstream neurodegeneration |
a. elevated cerebrospinal fluid tau (total and phosphorylated) |
b. decreased metabolism in temporal and parietal cortex on 18flurodeoxyglucose (FDG) positron emission tomography |
c. atrophy on MRI in temporal (medial, basal, and lateral) and medial parietal cortex |