Table 1.

Inclusion and exclusion criteria of the BioCog study.

Inclusion criteria

Exclusion criteria

• Age ≥65 years • European descent (Caucasian) • Major elective surgery with planned operation time ≥ 60 min • Ability to give informed consent

• MMSE score ≤ 23 points at inclusion • Neuropsychiatric morbidity (including addiction), which limits the conduction of the neurocognitive testing • Anacusis or hypacusis, which limits the conduction of the neurocognitive testing • Centrally acting medication (e.g. antidepressants or tranquillizers) • Homelessness or inability to reach patient for follow-up • Participation in another prospective interventional clinical study during hospital stay • Accommodation in an institution due to an offcial or judicial order • Missing informed consent for saving and handing out pseudonymous data