Figure 5:

Kynurenine transfer (A, B) through the placenta and KYNA production (C), determined ex vivo during a 120 min perfusion with a physiological concentration of kynurenine (0.5 μM; Controls) or 100 μM kynurenine (Kynurenine). Raw values shown in A and C were measured in the fetal eluate. See Materials and Methods for experimental details and definition of the transplacental transfer rate (TPT%). Data are the mean ± SEM (n=4-7 dams). *p<0.05, **p<0.01 (Mann-Whitney U test).