Table 3:
Side effects observed in at least 10 percent of patients and all grade 3-5 events while on study (N=31)
| Adverse Event | Grade 1-2 | Grade 3 | Grade 4 | Grade 5 |
|---|---|---|---|---|
| Diarrhea | 23 | |||
| Fatigue | 21 | 1 | ||
| Aspartate aminotransferase increased | 17 | 3 | ||
| Alanine aminotransferase increased | 15 | 3 | 1 | |
| Skin hyperpigmentation | 18 | |||
| Hypertension | 14 | |||
| Nausea | 12 | |||
| Dysgeusia | 10 | |||
| Proteinuria | 8 | 1 | ||
| Mucositis | 8 | |||
| Leukopenia | 8 | |||
| Alopecia | 8 | |||
| Vomiting | 7 | |||
| Platelet count decreased | 6 | |||
| Hair pigment change | 6 | |||
| Rash | 6 | |||
| Anemia | 5 | |||
| Alkaline phosphatase increased | 4 | |||
| Creatinine increased | 4 | |||
| Depression | 4 | |||
| Epistaxis | 4 | |||
| Hyperglycemia | 4 | |||
| Hyperthyroidism | 4 | |||
| Hypoalbuminemia | 4 | |||
| Hypernatremia | 3 | |||
| Hypocalcemia | 3 | |||
| Hypokalemia | 3 | |||
| Hyponatremia | 2 | 1 | ||
| Appendicitis | 1 | |||
| Gastritis | 1 | |||
| GGT increased | 1 | |||
| Peripheral Motor Neuropathy | 1 | |||
| Nervous system disorders - Other | 1 |