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. 2019 Jan 17;34(1):465–478. doi: 10.1080/14756366.2018.1555536

Table 1.

Effects of the compounds on the growth of SW620 human colon cancer cells.

graphic file with name IENZ_A_1555536_ILG0001.jpg

Cpd R R’/Ar CGP (%)a Cpd R R’/Ar CGP (%)a
5a -H H 41.70 ± 4.89 5r -Cl -H 78.58 ± 0.81
5b -H 2-Cl 3.88 ± 6.23 5s -Cl 4-F 86.71 ± 5.86
5c -H 2-NO2 79.18 ± 3.46 5t -Cl 4-OCH3 −4.75 ± 1.51
5d -H 3-Cl 83.23 ± 4.86 5u -CH3 -H 9.91 ± 2.26
5e -H 4-Cl 39.09 ± 4.17 5v -CH3 2-NO2 33.21 ± 7.89
5f -H 4-F 65.77 ± 7.72 5w -CH3 4-F 85.41 ± 2.89
5g -H 4-Br 54.46 ± 3.97 5y -CH3 4-Br 51.05 ± 7.38
5h -H 2-OH 35.50 ± 5.15 5x -CH3 4-OCH3 −13.24 ± 3.12
5i -H 4-OH 67.09 ± 8.29 5z -CH3 4-(NCH3)2 −12.43 ± 4.66
5j -H 4-OCH3 91.40 ± 9.78 6a -H graphic file with name IENZ_A_1555536_ILG0003.gif 83.73 ± 7.37
5k -H 2,3-(OH)2 33.40 ± 4.15 6b -H graphic file with name IENZ_A_1555536_ILG0004.gif 84.82 ± 7.72
5l -H 2,4-(OH)2 10.38 ± 2.44 6c -H graphic file with name IENZ_A_1555536_ILG0005.gif 69.25 ± 4.17
5m -H 2,5-(OH)2 74.70 ± 6.61 6d -H graphic file with name IENZ_A_1555536_ILG0006.gif 82.31 ± 4.31
5n -H 2-OH-4-OCH3 2.81 ± 3.61 6e -H graphic file with name IENZ_A_1555536_ILG0007.gif 84.00 ± 6.92
5o -H 3-OH-4-OCH3 78.68 ± 8.05 6f -H graphic file with name IENZ_A_1555536_ILG0008.gif 77.79 ± 7.49
5p -H 2,3,4-(OCH3)3 55.67 ± 6.37 6g -H graphic file with name IENZ_A_1555536_ILG0009.gif 88.32 ± 5.28
5q -H 3,4,5-(OCH3)3 37.76 ± 7.16 7a -H -H 85.58 ± 6.17
5-FUb 17.35 ± 9.01 7b -I -H −1.99 ± 5.14

aCell growth percentage, compounds were assayed at 30 µg/mL; b5-FU: 5-Fluorouracil, a positive control.