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. 2018 Dec 20;3(24):e97293. doi: 10.1172/jci.insight.97293

Figure 4. Loss of LPA4 results in increased mitochondria-related gene expression and serum adiponectin level on chow diet.

Figure 4

(A and B) Gene Ontology (GO) enrichment analysis of genes upregulated (A) and downregulated (B) in WAT from chow-fed Lpar4-KO mice compared with WT control mice (n = 4 each). Probe sets with FDR < 0.01 were regarded as differentially expressed. GO terms significantly enriched in analyses of both epididymal white adipose tissue (eWAT) and inguinal WAT (iWAT) are shown. (C) Relative expression of mitochondria-related genes in eWAT from chow-fed WT and Lpar4-KO mice. Data are expressed as the mean ± SEM (n = 12 each). (D) Serum adiponectin levels of chow-fed WT (n = 46) and Lpar4-KO (n = 32) mice. Each symbol represents an individual mouse. Data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, unpaired Student’s t test.