Skip to main content
. 2018 Dec 20;3(24):e123673. doi: 10.1172/jci.insight.123673

Figure 3. PMB versus NAB739/NAB741 demonstrates mitigated toxicity with analogs.

Figure 3

(A) Effluents were collected at 24 and 48 hours of treatment and analyzed for KIM-1 levels (n = 8 donors). Significant accumulation of KIM-1 in the effluent was observed only in the PMB group. (B) Cell-associated HMOX1. HMOX1 expression was measured by immunostaining, with no significant differences observed for either NAB739 or NAB741 relative to controls across several donors treated with 50 μM NAB739 (n = 3) and 50 μM NAB741 (n = 3) relative to controls (n = 5). Values are reported as the mean ± SD (****P < 0.0001).