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Representative confocal microscopy images tracking the uptake of NTHZN and THZN nanoplatforms in HT-29 cancer cells transfected with the lysosomal marker Rab7-GFP, under hypoxic conditions, at either 4 h or 24 h incubation time. The comparative intracellular trafficking of the two Au nanoplatforms and the dynamic of doxorubicin release from them reflects the impact of CA IX-mediated internalization under hypoxic conditions.
