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Synthesis of CA inhibitor targeting ligands 5 and 6, bearing the 2-succinylamido-1,3,4,-thiadiazole-5-sulfonamide pharmacophore attached to lipoic acid anchoring moieties via either a short or long EG linker. An amino-PEG lipoic acid conjugate 8 (without the CAI pharmacophore) was also synthesized to be used in control experiments.
