FIG 2.

Retrospective Randomized Evaluation of Molecular-Guided Therapy for Diffuse Large B-Cell Lymphoma With Bortezomib (REMoDL-B) trial analysis with the molecular high-grade (MHG) group. (A) Number of REMoDL-B patients with standard cell-of-origin (COO) classification (inner circle) and with MHG patients separated into a new class (outer circle). For the latter, the overall distribution between classes is shown in the histogram. (B) Progression-free survival (PFS) curves for rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP)–treated patients by classification, with MHG as a separate class. (C) As in (B) but for patients treated with R-CHOP with the proteasome inhibitor bortezomib (RB-CHOP). (D) As in (B), but overall survival (OS) for all patients. (E) Progression-free survival for MHG patients separated by treatment. P values given for overall difference in survival are from the likelihood ratio test and for individual groups with reference to the best-surviving group from a Cox proportional hazards regression model. ABC, activated B-cell-like; GCB, germinal center B-cell-like; HR, hazard ratio; NA, not applicable; UNC, unclassified.