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. 2018 Sep 11;40(1):236–267. doi: 10.1210/er.2018-00066

Figure 4.

Figure 4.

Fibrocytes express several proteins thought to be restricted to the thyroid. Expression of the proteins appears to depend on autoimmune regulator protein (AIRE). Fibrocytes collected from an individual with autoimmune polyendocrine syndrome type 1 (APS-1) express lower levels of AIRE, TSHR, thyroglobulin (Tg), sodium iodide symporter (NIS), thyroid peroxidase (TPO), pair-boxed 8 (PAX8), and thyroid transcription factor-1 (TTF-1) than do those from an unaffected, first-degree relative. Results from real-time PCR of the targets are indicated. [Reproduced with permission from Fernando R, Lu Y, Atkins SJ, Mester T, Branham K, Smith TJ. Expression of TSHR, thyroglobulin, sodium iodide symporter, and thyroteroxidase by fibrocytes depends on AIRE. J Clin Endocrinol Metab. 2014;99(7):E1236–E1244; © 2019 Illustration Presentation ENDOCRINE SOCIETY].