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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Trends Genet. 2018 Dec 13;35(2):93–103. doi: 10.1016/j.tig.2018.11.004

Figure 1: The founder fallacy.

Figure 1:

(A) A set of sequence fragments (e1–e4), each of which functions as an enhancer in a reporter gene assay. Fragment e2 is active in both Tissue A and Tissue B, identical to e1, but was identified more recently. e3 and e4 each have a subset of the function of e1 and e2, with distinct activity. (B) In this second set of sequence fragments, the more recently-identified e2 is longer than the original e1 enhancer, but lacks ectopic regulatory activity in Tissue C. Thus e2 is more properly the “true” enhancer than the shorter e1.