. Author manuscript; available in PMC: 2020 Feb 1.

Published in final edited form as: Trends Genet. 2018 Dec 27;35(2):159–172. doi: 10.1016/j.tig.2018.12.002

Table 1 –

Non-covalent ADPr binding motifs

Motif	Abbreviation	Description	Moiety Read	Examples
Poly(ADP-ribose)-binding motif	PBM	~20 aa motif (hydrophobic aa spaced by basic aa)	Unknown	AIF (47), WRN (57), histone H2A/H2B/H3/H4 (119), p53 (59) XPA, p21, XRCC1/5/6, DNA-PK_cs, TOPI, DNA ligase 3 (54)
WWE		~80–100 aa	iso-ADP-ribose	Iduna/RNF146 (72), HUWE1, ULF, Deltex1, Deltex2, Deltex4, PARP11 (71)
Macro		130-190 amino acid motif	terminal ADP-ribose	ALC1 (63, 69), MacroH2A (120), PARP9, PARP14, PARP15, PARG, TARG1, MacroD1, MacroD2 (60)
PAR-binding zinc finger	PBZ	~30 aa Cys2-His2 (C8-C8-H8-H)	Two adjacent ADP-ribose moieties	APLF (121), CHFR (122), CTCF (123)
PAR-binding regulatory motif	PbR	Cys2-His2 (C8-C6-H8-H)	Unknown	CHK1 (124)