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. Author manuscript; available in PMC: 2020 Jan 17.
Published in final edited form as: Cell Chem Biol. 2018 Nov 1;26(1):131–136.e4. doi: 10.1016/j.chembiol.2018.10.006

Figure 1. Targeting CD169 via Liposomal Nanoparticles.

Figure 1.

(A) Schematic of AF-LP-CD169L (B) Performance of CD169-targeted liposomes in vitro using CD169 knock-in THP-1 cells. Solid and dashed histograms represent WT and CD169 knock-in THP-1 cells respectively. AF-LP-CD169L and AF-LP correspond to liposomes with and without CD169L respectively. Numbers represent median fluorescence intensity normalized to the PBS control. (C) Competitive uptake of liposomes between subpopulations of splenic macrophages in vivo. Numbers represent the percentage of cells within the AF555+ region (right side of dashed line). (D) Quantification of data in B. Each symbol corresponds to an individual animal. Error bars represent SD. *P<0.05, **P<0.01. (E) Confocal microscopy images of murine spleen from mice injected with either AF-LP or AF-LP-CD169L. AF555 (red) / α-CD169 (green) / Hoechst nuclear dye (blue). WP and RP represent white pulp and red pulp respectively.