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. Author manuscript; available in PMC: 2020 Jan 17.
Published in final edited form as: Cell Chem Biol. 2018 Nov 1;26(1):131–136.e4. doi: 10.1016/j.chembiol.2018.10.006

Figure 3. Delivery of antigen to TLR7-activated CD169MØs enables CD8+ T cell priming.

Figure 3.

. (A) Classical activation of F4/80hi and CD169+ macrophages through stimulation with liposomes bearing TLR7L in vivo. Cells populating the CD80+CD86+ quadrant are considered activated (grey, orange, and red squares). Numbers represent the percentage of activated cells. (B) Schematic of CD169-targeted liposomes bearing CD169L and TLR7L (TLR7L-LP-CD169L). (C) Quantification of data in A. (D) Proliferation histograms for adoptively transferred CTV stained OT-II or OT-I cells in Ly5b+/+ mice injected with both OVA-LP(-CD169L) and TLR7L-LP-CD169L. Numbers represent cell division indexes. (E) Quantification of data in D. ***P<0.001.