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. Author manuscript; available in PMC: 2020 Jan 17.
Published in final edited form as: Cell Chem Biol. 2018 Nov 1;26(1):131–136.e4. doi: 10.1016/j.chembiol.2018.10.006

Figure 4. CD169-targeted antigen delivery coupled with TLR7-induced activation provides control over CD4+:CD8+ T cell ratios in a single organism.

Figure 4.

(A) Schematic of co-adoptive transfer experiments. Equal numbers of CTV stained OT-II (Ly5a+/+) and OT-I (Ly5b+/−Ly5a−/+) cells were adoptively transferred into WT Ly5b+/+ host mice. Host mice were then injected with OVA-LP-CD169L (blue) or OVA-LP-CD169L + TLR7L-LP-CD169L (red). (B) Gating strategy for identifying adoptively transferred OT-II and OT-I cells from the same host. (C) OT-II and OT-I cell proliferation histograms from individual mice. Vertical plots represent OT-II and OT-I proliferation from the same mouse. Numbers represent division indexes. (D) Quantification of data in C.