. Author manuscript; available in PMC: 2020 Feb 1.

Published in final edited form as: J Intern Med. 2018 Sep 17;285(2):215–222. doi: 10.1111/joim.12829

Table 3.

Gene-based association analysis with Congenital Zika Syndrome in the cohort from Campina Grande, Brazil

Gene	Variants analyzed (N)		SKAT results (P-value)
Gene	Rare	Common	Crude	Adjusted^*
ADCY3	2	9	0.00191	0.00115
ADCY7	2	3	0.00146	0.00180
ADCY10	6	15	0.07424	0.01397
AKAP1	7	17	0.06081	0.04884
AKAP3	2	10	0.06084	0.03914
AKAP8	2	5	0.04259	0.06712
COL1A2	2	10	0.02810	0.02797

Results were obtained from a SKAT model allowing for the joint effect of common and rare variants.

Results adjusted for gestational age at the moment of infection (first trimester or other). P-values that remained statistically significant after Bonferroni adjustment for multiple comparisons (α = 0.00294) are shown in bold.