Table 2:
Tissue Type/Region | Vmax (pmol/min/mg) |
Km (μM) |
Reference |
---|---|---|---|
Rat | |||
Striatal Synaptosomes (including NAc and CPu) | 6 – 159 | 0.03 – 0.50 | (Afonso-Oramas et al., 2009; Carvelli et al., 2002; Foster and Vaughan, 2011; Hong and Amara, 2010; Jones et al., 2017; Moritz et al., 2013; Morón et al., 2003; Richards and Zahniser, 2009; Vaughan et al., 1997; Zahniser et al., 1999) |
VTA Slices | 0.33 ± 0.03a | (Mebel et al., 2012) | |
Striatum (in vivo) | 0.7a | 10 – 12 (KT) | (Sabeti et al., 2002; Zahniser et al., 1999) |
Mouse | |||
Striatal Synaptosomes | 38 ± 7 | 0.06 ± 0.01 | (Rao et al., 2013) |
NAc Slices | 1.0a | 0.2 | (Lu et al., 2015) |
Human | |||
Striatal Synaptosomes | 0.41 | (Mash et al., 2002) | |
Drosophila | |||
Channelrhodospin2 (ChR2) DA neurons | 0.11 ± 0.02a | 1.3 ± 0.6 | (Vickrey et al., 2013) |
μM/s