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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Neurochem Int. 2018 Sep 1;123:13–21. doi: 10.1016/j.neuint.2018.08.015

Table 2:

Vmax and Km values determined for DA transport in animal tissues and brain regions.

Tissue Type/Region Vmax
(pmol/min/mg)
Km
(μM)
Reference
Rat
Striatal Synaptosomes (including NAc and CPu) 6 – 159 0.03 – 0.50 (Afonso-Oramas et al., 2009; Carvelli et al., 2002; Foster and Vaughan, 2011; Hong and Amara, 2010; Jones et al., 2017; Moritz et al., 2013; Morón et al., 2003; Richards and Zahniser, 2009; Vaughan et al., 1997; Zahniser et al., 1999)
VTA Slices 0.33 ± 0.03a (Mebel et al., 2012)
Striatum (in vivo) 0.7a 10 – 12 (KT) (Sabeti et al., 2002; Zahniser et al., 1999)
Mouse
Striatal Synaptosomes 38 ± 7 0.06 ± 0.01 (Rao et al., 2013)
NAc Slices 1.0a 0.2 (Lu et al., 2015)
Human
Striatal Synaptosomes 0.41 (Mash et al., 2002)
Drosophila
Channelrhodospin2 (ChR2) DA neurons 0.11 ± 0.02a 1.3 ± 0.6 (Vickrey et al., 2013)
a

μM/s