FIG. 3.

Bar graphs demonstrating comparisons of (A) percent brain water (%BW) as a measure of brain edema (n = 5 per genotype), and (B) Evans blue dye test to investigate blood–brain barrier (BBB) permeability in a controlled cortical impact (CCI) model in wild-type (WT) and high mobility group box 1 (HMGB1) knockout (KO) mice (n = 10 per genotype). Overall, no significant difference was noted in %BW and Evans blue dye leakage in both the ipsilateral and contralateral hemisphere in the HMGB1 KO mice, compared with the WT mice (p > 0.05).