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Representative microphotographs stained with hematoxylin and eosin (H&E), depicting the CA1 (A) and CA3 (B) hippocampal subfield in wild-type (WT) and high mobility group box 1 (HMGB1) knockout (KO) mice at 21 days post–controlled cortical impact (CCI; n = 10 per genotype). No statistically significant difference was noted in neuronal survival between WT and HMGB1 KO mice in the CA1 or CA3 hippocampus (p = 0.07).
