FIG. 8.

The hexamerization hot spot of GSALDH. (A) The hexamer of yeast GSALDH showing the location of the hexamerization hotspot (PDB code 4OE6). (B) Close-up view of the hot spot of TtGSALDH. Arg100 occupies the center of the hot spot and is essential for hexamer formation. (C) Close-up view of the hot spot of yeast GSALDH. Trp193 occupies the center of the hotspot and is essential for hexamer formation. Figure adapted from Luo et al. (73) and Pemberton et al. (91). To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars