Classification of PutAs according to domain architecture and global sequence identity. (A) The three domain architectures of PutAs. (B) Phylogenetic tree based on global sequence alignments of PutAs. PutAs with architecture types A, B, and C are indicated by black, blue, and red genus names, respectively. Large bold font denotes PutAs mentioned in the text. The alignments were calculated with Clustal Omega (116). The tree was made with DrawTree (27). The sequences used to make this tree are provided in Supplementary Data (Supplementary Data are available online at www.liebertpub.com/ars). PutAs, proline utilization A. Figure taken from Korasick et al. (51). To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars