Table 4.
Risk of placental complications by maternal co-morbidities, fertility group, and plurality
| Plurality | Singletons | Twins | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Factor | Model | Outcome | Other | Placenta | Abruptio | Other | Placenta | Abruptio | ||||||
| Excessive bleeding | Previa | Placenta | Excessive bleeding | Previa | Placenta | |||||||||
| Model 1 | N | 651,746 | 854,999 | 1,524,996 | 22,352 | 29,375 | 49,915 | |||||||
| N, % | 5536 | 0.8% | 4218 | 0.5% | 7314 | 0.5% | 655 | 2.9% | 295 | 1.0% | 509 | 1.0% | ||
| Model 2 | N | 43,160 | 55,723 | 99,401 | 17,343 | 22,907 | 39,014 | |||||||
| N, % | 741 | 1.7% | 1164 | 2.1% | 799 | 0.8% | 615 | 3.5% | 323 | 1.4% | 426 | 1.1% | ||
| AOR | 95% CI | AOR | 95% CI | AOR | 95% CI | AOR | 95% CI | AOR | 95% CI | AOR | 95% CI | |||
| Diabetes | Model 1 | None | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| Pregestational | 1.53 | 0.95, 2.48 | 0.80 | 0.48, 1.33 | 1.02 | 0.76, 1.37 | 1.03 | 0.14, 7.51 | – | – | 0.38 | 0.05, 2.72 | ||
| Gestational | 1.28 | 1.04, 1.58 | 1.03 | 0.86, 1.24 | 0.93 | 0.83, 1.05 | 1.23 | 0.63, 2.37 | 1.43 | 0.82, 2.52 | 0.79 | 0.53, 1.19 | ||
| Model 2 | None | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | |
| Pregestational | 0.46 | 0.06, 3.27 | 1.01 | 0.44, 2.32 | 1.69 | 0.83, 3.44 | – | – | 0.85 | 0.12, 6.19 | 0.26 | 0.02, 4.25 | ||
| Gestational | 1.01 | 0.60, 1.68 | 0.79 | 0.55, 1.13 | 1.41 | 1.08, 1.84 | 1.26 | 0.65, 2.45 | 1.10 | 0.61, 1.99 | 0.83 | 0.55, 1.25 | ||
| Hypertension | Model 1 | None | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| Pregestational | 1.37 | 1.12, 1.67 | 0.49 | 0.36, 0.68 | 1.77 | 1.52, 2.07 | 1.06 | 0.55, 2.02 | 1.00 | 0.41, 2.44 | 1.40 | 0.75, 2.61 | ||
| Gestational | 1.52 | 1.34, 1.72 | 0.54 | 0.44, 0.65 | 1.96 | 1.79, 2.14 | 1.31 | 0.98, 1.74 | 0.50 | 0.30, 0.83 | 0.82 | 0.59, 1.15 | ||
| Model 2 | None | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | |
| Pregestational | 1.39 | 0.88, 2.20 | 0.61 | 0.37, 1.01 | 1.79 | 1.21, 2.65 | 1.05 | 0.58, 1.89 | 0.45 | 0.14, 1.41 | 0.83 | 0.37, 1.88 | ||
| Gestational | 1.02 | 0.73, 1.42 | 0.55 | 0.40, 0.74 | 1.16 | 0.87, 1.56 | 1.27 | 0.98, 1.66 | 0.58 | 0.38, 0.87 | 0.77 | 0.54, 1.08 | ||
| Fertility | Model 1 | Fertile | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| Group | Subfertile | 1.49 | 0.77, 2.89 | 1.30 | 0.73, 2.32 | 1.52 | 1.11, 2.06 | 2.09 | 0.64, 6.81 | 1.14 | 0.22, 5.97 | 1.16 | 0.62, 2.17 | |
| IVF | 1.53 | 1.38, 1.70 | 3.79 | 3.48, 4.13 | 1.68 | 1.52, 1.85 | 1.16 | 0.97, 1.37 | 2.19 | 1.63, 2.94 | 1.23 | 0.99, 1.52 | ||
| Model 2 | A-fresh | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | |
| A-thawed | 1.49 | 1.24, 1.80 | 0.54 | 0.45, 0.65 | 0.63 | 0.51, 0.78 | 1.26 | 0.99, 1.61 | 0.66 | 0.44, 0.99 | 0.75 | 0.54, 1.04 | ||
| D-fresh | 1.52 | 1.16, 2.00 | 0.74 | 0.59, 0.93 | 0.87 | 0.66, 1.14 | 1.76 | 1.31, 2.34 | 0.90 | 0.61, 1.32 | 0.93 | 0.66, 1.31 | ||
| D-thawed | 0.83 | 0.52, 1.34 | 0.68 | 0.50, 0.94 | 0.73 | 0.49, 1.08 | 1.58 | 0.98, 2.54 | 1.15 | 0.63, 2.10 | 0.57 | 0.27, 1.19 | ||
Models adjusted for maternal age, parity, hypertension and diabetes (pregestational and gestational), placental complications (placenta previa, abruptio placenta, and excessive bleeding), mode of delivery, infant sex, length of gestation, small-for-gestation birthweight, State of residence, year of birth, and fertility status. For model 1, the study population was categorized by fertility status as fertile (reference), subfertile, and IVF (limited to autologous-fresh cycles only); for model 2, the study population was limited to IVF-conceived pregnancies as autologous-fresh (reference), autologous-thawed, donor-fresh, donor-thawed
Italicized AORs and 95% CIs are increased; those that are additionally emphasized in bold are significantly increased