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. 2018 Oct 10;33(2):2563–2573. doi: 10.1096/fj.201800754RR

Figure 2 .

Figure 2

Metabolites in the brain (A, B) and liver (C, D) of Cd320+/+ and Cd320−/− groups fed a normal diet, a Cbl-deficient diet, or a Cbl-deficient diet supplemented with folic acid. A, B) Significant changes were observed in the concentration of methionine, cystathionine, and SAM:SAH ratio in the brain, but not in the levels of SAM and SAH (A) or betaine and choline (B). C, D) The profile of liver metabolites varied considerably from that in brain tissue. The SAM (C):SAH ratio was increased in Cd320+/+-Cbl− and Cd320−/−-Cbl− mice and decreased in Cd320−/−-Cbl−F+ mice. Cystathionine (D) was increased only in the Cd320−/−-Cbl− group, and betaine was increased only in the Cd320−/−-Cbl− group (n = 5 for each group). *P < 0.05.