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. 2018 Sep 11;33(2):1578–1594. doi: 10.1096/fj.201800395RR

Figure 1 .

Figure 1

RTX-mediated sensory denervation protected against psoriasis-like skin pathology and associated discomfort. A, B) In vivo change in double-fold skin thickness (mm) (A) and dorsal skin blood flow (B). C) Epidermal thickness measured and representative images of H&E-stained skin samples sectioned at 10 μm thickness (right). Original magnification, ×10. Scale bar, 100 μm. D) Total spontaneous behaviors on d 4. E) Total number of hind paw scratching events. F) Total number of biting/licking events. G) Total number of flinching events. VEH, vehicle. Graphs represent means ± sd, and data were analyzed by repeated measures 2-way ANOVA with Bonferroni’s post hoc test; n = 5–7 animals/group.*P < 0.05, **P < 0.01, ***P < 0.001 between Vaseline vs. Aldara group, ###P < 0.001 between VEH vs. RTX, $P < 0.05 between Vaseline VEH vs. Vaseline RTX.