Figure 7 .

TRPV1 and α-CGRP deletion showed a significant reduction in spontaneous behaviors independent of the development of skin pathology. A) Change in double-fold skin thickness (mm). B) Dorsal skin blood flow. C) Total d 4 spontaneous behaviors in TRPV1 wild type (WT), TRPV1 KO, or α-CGRP KO groups. D) Total number of hind paw scratching events. E) Total number of biting/licking events. F) Total number of flinching events. Graphs represent means ± sd, and data were analyzed by 1-, 2-way, or repeated-measures ANOVA with Bonferroni’s post hoc test; n = 5–6 animals/group. **P < 0.01, ***P < 0.001 Vaseline vs. Aldara, ^##P < 0.001 WT vs. α-CGRP KO, ^$P < 0.05 WT vs. TRPV1 KO.