Figure 2 .

Normalization of ADN levels in obese pregnant mice largely prevents insulin resistance in offspring. GTT (A, B, E, F) and IRT (C, D, G, H). Blood glucose was measured over 120 min after glucose load (A, E) and insulin load (C, G) in offspring. AUC of GTT (B, F), measure of glucose tolerance, and IRT (D, H), readout of insulin resistance. Males (A–D) and females (E–H) were studied separately. Means ± sem; n = 6–10 per group. Different letters (a–c) denote statistically significant differences. P < 0.05.