Skip to main content
. 2018 Aug 29;33(2):1605–1616. doi: 10.1096/fj.201800965R

Figure 4 .

Figure 4

Oxidative stress induces miRNA-570-3p expression in a p38-c-jun–dependent manner. A) MiR-570-3p expression in BEAS-2B cells after H2O2 treatment (n = 5). B–E) p38MAPK inhibitor VX745 (100 nM) effect on miR-570-3p (B), pri-miR-570-3p (C), sirtuin-1 (D), and p21Waf1 (E) gene expression in BEAS-2B cells treated with or without H2O2 (n = 6). F–H) MiR-570-3p (F), sirtuin-1 (G), and p21Waf1 (H) gene expression in BEAS-2B cells were transfected with c-Jun siRNA (100 nM) or random oligonucleotide and then treated with or without H2O2 (n = 6). Data are means ± sem and were analyzed by using Kruskal-Wallis test with post hoc Dunn’s test, 1-way ANOVA with post hoc Bonferroni correction, unpaired or paired Student’s t test, and Wilcoxon signed rank test; *P < 0.05, **P < 0.01, ***P < 0.001.