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. 2018 Oct 5;33(2):2537–2552. doi: 10.1096/fj.201800502R

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Kcne5 gene deletion augments I_K,slow2 in ventricular septum myocytes lacking I_to,f. A) Typical current traces from Kcne5^+/0 and Kcne5^−/0 adult ventricular septum myocytes (voltage protocol inset). B) Mean I-V relationships for Kcne5^+/0 (solid) and Kcne5^−/0 (open) septal myocytes with (squares) or without (circles) I_to,f (n = 15–19 cells per group). *P < 0.05 at +60 mV. C) Typical digitally subtracted 25 mM TEA-sensitive K_V2.1 current (I_K,slow2) for Kcne5^+/0 (left) and Kcne5^−/0 (right) ventricular septum myocytes. D) Mean I-V relationships for TEA-sensitive currents as in C (n = 6 cells/genotype, derived from 2 mice/genotype). **P = 0.009 at +60 mV. E) Typical digitally subtracted current traces for 50 μM 4-AP-sensitive K_V1.5 current (I_K,slow1) for Kcne5^+/0 (left) and Kcne5^−/0 (right) ventricular myocytes. Dashed lines: 0 current level. F) Mean I/V relationships for myocytes as in E (n = 8 cells/genotype, derived from 2 mice/genotype). P = 0.984 at +60 mV. Dashed lines: 0 current level.