TABLE 1.
Fitted KV current densities and inactivation kinetics in ventricular apex and septum myocytes from Kcne5+/0 and Kcne5−/0 mice at +40 mV
| Genotype and myocyte type | I to,f | I to,s | I K,slow | n |
|---|---|---|---|---|
| Kcne5+/0 apex | 68.6 ± 2.5 | NA | 1351 ± 59.5 | 27 |
| 14.7 ± 0.9 | NA | 8.5 ± 0.6 | 27 | |
| Kcne5+/0 septum, with Ito,f | 52.1 ± 3.3 | 526.3 ± 35 | 3869 ± 943 | 19 |
| 14.3 ± 1.6 | 9.2 ± 0.5 | 11.2 ± 1.0 | 19 | |
| Kcne5+/0 septum, no Ito,f | NA | 165.7 ± 11.6 | 1601.8 ± 76 | 16 |
| NA | 5.8 ± 0.8 | 9.5 ± 1.1 | 16 | |
| Kcne5−/0 apex | 66.7 ± 2.6 | NA | 1134 ± 31.4*** | 31 |
| 17.5 ± 0.9 * | NA | 11.6 ± 0.7*** | 31 | |
| Kcne5−/0 septum, with Ito,f | 40.8 ± 1.8** | 383.9 ± 22.8*** | 1857 ± 135 | 15 |
| 16.3 ± 1.4 | 8.6 ± 1.1 | 11.2 ± 1.1 | 15 | |
| Kcne5−/0 septum, no Ito,f | NA | 159.2 ± 15 | 1250 ± 88*** | 16 |
| NA | 8.5 ± 1.4 | 12.9 ± 1.7 * | 16 |
Values are means ± se. Current properties: τdecay (ms); I (pA/pF). I, current density; τdecay, inactivation time constant; n, number of cells; NA, not applicable (current not present). Statistically significant changes in current density are underlined.
*
P < 0.05, **P < 0.01, ***P < 0.005 vs. equivalent criteria in WT mice.