Figure 1 .

Epac1^−/− and Epac2^−/− mice developed polyuria. A) Summary graph comparing 24 h urinary volume in age-matched Epac WT, Epac1^−/−, and Epac2^−/− mice placed in metabolic cages. B) Summary graph of urine spot osmolarity of Epac WT, Epac1^−/−, and Epac2^−/− mice in unstressed condition. C) Summary graph comparing serum osmolarity of Epac WT, Epac1^−/−, and Epac2^−/− mice. Number of mice indicated on each bar. *P < 0.05 vs. Epac WT, estimated by 1-way ANOVA.