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Lack of apparent solute wasting in Epac1−/− and Epac2−/− mice at baseline. Summary graphs show averaged AVP normalized to respective creatinine (A), Na+ (B), and urea (C) levels in 24 h urine samples from Epac WT, Epac1−/−, and Epac2−/− mice placed in metabolic cages. *P < 0.05 vs. Epac WT. Number of mice in each group is indicated on each bar.
