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Augmented urinary sodium and urea excretion in water-deprived Epac1−/− and Epac2−/− mice. Summary graphs showing averaged Na+ (A) and urea (B) levels in urine samples from Epac WT, Epac1−/−, and Epac2−/− mice placed in metabolic cages after 24 h of water deprivation. *P < 0.05 vs. Epac WT. Number of mice in each group is indicated on each bar.
