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. 2018 Oct 23;33(2):3024–3034. doi: 10.1096/fj.201801002R

Figure 1 .

Figure 1

Treatment with 1NMPP1 for 4 wk inhibits resistance in MA-challenged mice. A) Experimental design of MA challenge and 1NMPP1 administration to TrkBKI or C57Bl/6J mice. B) The effects of MA on resistance and compliance during methacholine challenge are inhibited in TrkBKI mice treated with 1NMPP1. C, D) The effects of 1NMPP1 on resistance and compliance are absent in TrkBKI mice treated with 1NMPP1 for the last 2 wk (C) and C57Bl/6J mice treated with 1NMPP1 for 4 wk (D). Data are presented as means ± sem (n = 6–12 for TrkBKI and n = 7–8 C57Bl/6J mice/group). *P < 0.05, significant difference between control and MA; **P < 0.05, significant difference between control and MA + 1NMPP1; $P < 0.05, significant difference between MA and 1NMPP1 + MA.