Figure 4 .

H67D-mutant mice exhibit increased exploratory activity and decreased anxiety. WT and H67D-mutant mice were subjected to elevated plus maze (EPM) task at age 7 or 8 wk for assessment of anxiety-like behavior, including total distance in whole maze (A) and distance traveled (B), entries (C), and time spent in open and closed arms (D). Empty and solid bars represent WT and H67D-mutant mice, respectively. Data are presented as means ± sem (n = 8–10/group), and significant differences were analyzed by Student’s t test. *P < 0.05 vs. WT.