Table 3.
Parent-of-origin eQTLs in LCLs
| Phenotype | Sample size | rsid | chr:loc | Gene | Beta (SE) | Maternal eQTL p-value | Paternal eQTL p-value |
|---|---|---|---|---|---|---|---|
| A Maternal associations | |||||||
| CIMT | 334 | rs4077567 | 1:216703202 | ABCA12 | 0.039 (0.017) | 2.14E–02 | 1.53E–02 |
| Age of menarche | 336 | rs7184983 | 16:56554709 | POLR2C | −0.085 (0.039) | 2.91E–02 | 7.93E–01 |
| Age of menarche | 336 | rs7184983 | 16:56554709 | SLC12A3 | −0.064 (0.031) | 3.77E–02 | 2.28E–01 |
| CIMT | 334 | rs4077567 | 1:216703202 | RPL37A | 0.030 (0.016) | 5.72E–02 | 5.90E–01 |
| LVM | 457 | rs74232282 | 1:41662388 | SMAP2 | 1.40 (0.159) | 5.82E–02 | 1.12E–01 |
| B Paternal associations | |||||||
| Total cholesterol | 352 | rs113588203 | 1:228979165 | HIST3H2A | 0.560 (0.308) | 8.81E–01 | 6.85E–02 |
| Total cholesterol | 352 | rs113588203 | 1:228979165 | SPHAR | 0.073 (0.047) | 6.01E–01 | 1.20E–01 |
| LDL | 352 | rs1110603 | 16:87687317 | MAP1LC3B | −0.024 (0.015) | 4.35E–01 | 1.25E–01 |
| LDL | 352 | rs1110603 | 16:87687317 | FBXO31 | −0.027 (0.018) | 1.56E–01 | 1.36E–01 |
| Total cholesterol | 357 | rs113588203 | 1:228979165 | RAB4A | −0.039 (0.028) | 6.16E–01 | 1.59E–01 |
The most significant SNP for each phenotype (Table 1) was tested for association with gene expression for genes with TSS within 1 Mb of the SNP. The effect sizes correspond to the maternal (A) or paternal (B) effect sizes. Only the five most significant SNPs are listed for each parental eQTL