Table II.

Criteria for the Clinical Diagnosis of NF1 (At least two are required)

Criterion	Notes
Six or more café-au-lait macules	>5 mm before puberty
	>15 mm after puberty
Freckling	Axillary, inguinal
Neurofibromas	Two or more neurofibromas or one plexiform neurofibroma
Skeletal dysplasia	Sphenoid or tibial lesion
Lisch nodules	Two or more iris hamartomas
Optic glioma	Detected by imaging (usually MRI)
First degree relative with NF1	Sibling or parent with NF1

(NIH Consensus Development Conference 1988)