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. 2019 Jan 18;10:334. doi: 10.1038/s41467-018-08098-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Collateral response following evolution under cefotaxime. The maximum likelihood estimates for the MICs of replicates X1–X60 under cefotaxime and eight other antibiotics. Small markers indicate individual measurements (taken in triplicate). Marker colour indicates fold-change from wild-type sensitivity (increased sensitivity—blues, increased resistance—reds). Significance is determined via a likelihood ratio test (see Methods) and Bonferroni (BF) corrected. Precise p values are reported in Supplementary Dataset 1