Fig. 7.
Sustained SAMβA treatment results in better heart failure outcome. a Left ventricular ejection fraction and b LVEDd (left ventricular end-diastolic dimension) measured by echocardiography before and after treatment; input: delta of measurements performed before and after treatment, in animals from sham (white bars, n = 7), TAT-treated heart failure (HF-Ctr, gray bars, n = 9), βIIV5-3-treated heart failure (HF-βIIV5-3, red bars, n = 7), and SAMβA-treated heart failure groups (HF-SAMβA, blue bars, n = 11). Data are means ± SEM. *P < 0.05 vs. Sham rats. #P < 0.05 vs. HF-Ctr rats. &P < 0.05 vs. before treatment. One-way or two-way analyses of variance (ANOVA) with post-hoc testing by Duncan. For all the cardiac function studies, the observer was blinded to the experimental groups. c Proposed model for the SAMβA-mediated cardioprotection in post-myocardial infarction-induced heart failure