Table 1.
Characteristics of differential methylation
| Comparison | Tool | DMCs | DMRs | DMRs by type | DMCs in DMRs | % DMCs in DMRs | % DMR CpGs that are DMCs | DMR % of autosomes |
|---|---|---|---|---|---|---|---|---|
| B6 vs. C3 | DSS | 72,275 | 6380 | B6 > C3 3166 C3 > B6 3214 |
47,029 | 65.1 | 65.5 | 0.143 |
| Metilene | 185,194 | 2569 | B6 > C3 1262 C3 > B6 1307 |
23,839 | 12.9 | 78.8 | 0.042 | |
| Male vs. female (B6 + C3 animals) | DSS | 12,224 | 1575 | M > F 534 F > M 1041 |
8532 | 69.8 | 58.4 | 0.036 |
| Metilene | 51,675 | 439 | M > F 172 F > M 267 |
3426 | 6.6 | 81.1 | 0.008 | |
| Male vs. female (B6 animals) | DSS | 7400 | 1083 | M > F 415 F > M 668 |
5108 | 69.0 | 51.8 | 0.020 |
| Metilene | 37,327 | 70 | M > F 25 F > M 45 |
653 | 1.8 | 54.6 | 0.002 | |
| Male vs. female (C3 animals) | DSS | 11,142 | 1539 | M > F 548 F > M 991 |
7495 | 67.3 | 53.1 | 0.029 |
| Metilene | 62,785 | 93 | M > F 29 F > M 64 |
1018 | 1.6 | 64.4 | 0.003 | |
| Male vs. female (F1 animals) | DSS | 6007 | 720 | M > F 65 F > M 655 |
4053 | 67.5 | 59.1 | 0.017 |
| Metilene | 32,574 | 207 | M > F 26 F > M 181 |
1655 | 5.1 | 83.2 | 0.004 | |
| Parental female vs. virgin female | DSS | 2257 | 305 | p > v 10 v > p 295 |
1467 | 65.0 | 51.7 | 0.006 |
| Metilene | 17,798 | 68 | p > v 2 v > p 66 |
437 | 2.5 | 61.8 | 0.001 |