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. 2019 Jan 18;9:208. doi: 10.1038/s41598-018-36312-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased sumo-1/2/3 levels were detected in LMP1-positive lymphoma tissues in an LMP1-dependent manner. (a,b) RNA was extracted from 42 biopsy tissues and cDNA was made. Real-time PCR was performed to quantitate gapdh, LMP1, and sumo-1 levels. RNA yields allowed sumo-2/3 levels to be tested in 17 of the 42 samples. (a) Relative LMP1, sumo-1 and sumo-2/3 levels (relative to gapdh) were determined. The detection of LMP1 RNA levels determined is tissues were LMP1-negative (LMP1-neg) and LMP1-positive (LMP1-pos). Results are shown as the mean relative sumo-1 and sumo-2/3 levels for individual samples (shapes). Horizontal lines represent man sumo-1 and sumo-2/2 levels for the collective LMP1-neg and LMP1-pos samples. (b) Of the 19 LMP1-positive tissue samples, relative sumo-1 levels were determined in all 19 samples but relative sumo-2/3 levels were determined in only 9 samples. Results are shown as the mean relative LMP1, sumo-1, and sumo-2/3 leves of samples run in duplicate. Regression analysis was performed.