Figure 6.

Seven days of CS exposure does not increase markers of oxidative stress in lungs from RAGE null mice. (a) Quanitification of western blot data. Statistical significance determined by Student’s t-test. Lungs from control WT mice (5) or all other groups (4) of male mice were analyzed. (b) Full-length gels of 4-HNE-modified proteins analyzed by western blotting using lung homogenates from control and CS-exposed mice. 4-HNE modified proteins were increased in WT lungs by CS exposure. Although increased in control RAGE null lungs as compared with WT lungs, 7 days of CS did not result in an additional increment in 4-HNE staining in lungs of RAGE null mice.