Table 1.
Characteristics of included studies
| Author | Gene | Technique | Molecular Template | Sample | Setting | Age | Study Design | N |
|---|---|---|---|---|---|---|---|---|
| Penney 2016 | TMPRSS2:ERG | Immunohistochemical x Microarrays | Protein | Tissue | USA | 40–84 | Cohort | 487 |
| Sanda 2015 | TMPRSS2:ERG | mRNA | RNA | Urine | USA | 55–60 | Prospective multi-center study | 1077 (516) |
| Park 2014 | TMPRSS2:ERG | Inmunohistochemical x Monoclonal ERG antibody | Protein | Tissue | USA | Median 65 | Randomized phase III, double-blinded, placebo-controlled clinical | 1590 (461) |
| Tavukcu 2013 | TMPRSS2:ERG | RT-PCR | RNA | Tissue, Peripheral blood, Urine, Pubic hair | Turkey | 43–78 | Cohort | 50 |
| Lin 2013 | TMPRSS2:ERG | RT-PCR | RNA | Urine | USA | NA | Prospective, observational, active surveillance study | 387 |
| Leyten 2012 | TMPRSS2:ERG | mRNA | RNA | Urine | Netherlands | 44–86 | Prospective multicenter cohort | 443 |
| Tomlins 2011 | TMPRSS2:ERG | Transcription-mediated amplification (Malign)/FISH assay (Benign) | RNA/DNA | Urine (Malign) /Tissue (Benign) | USA/Canada | 56–65 | Cohort | 1312 |
| Mosquera 2009 | TMPRSS2:ERG | FISH | DNA | Tissue | USA | 54–70 | Cohort | 140 (134) |
| Laxman 2008 | TMPRSS2:ERG | RT-PCR | RNA | Urine | USA | NA | Cohort | 234 |
| Maekawa 2014 | TMPRSS2 | Real Time PCR SNP SondaTagMan | DNA | Blood | Japan | 48–100 | Cases and controls | 518 |
| Chan 2013 | TMPRSS2:ERG | RT-PCR | RNA | Urine | Canada | Median 68 | Cohort | 92 |
| Cornu 2013 | TMPRSS2:ERG | TaqManTM assays | DNA | Urine | France | 59–68 | Cohort | 291 |
| Robert 2013 | TMPRSS2:ERG | RT-PCR | DNA | Tissue | Netherlands | NA | Cohort? | 128 (96) |
| Huang 2011 | TMPRSS2:ERG | Immunohistochemical microarray | Protein | Tissue | USA | NA | Retrospective cohort | 80 |
| Nguyen 2011 | TMPRSS2:ERG | RT-PCR | RNA | Urine | Canada | 19–88 | Cases and controls | 101 |
| Albadine 2009 | TMPRSS2:ERG | FISH | DNA | Tissue | USA | NA | Cohort | 92 |
| Dimitriadis 2013 | TMPRSS2:ERG | RT-PCR TagMan | DNA | Urine | Greece | 45–83 | Cohort | 66 |
| Salami 2013 | TMPRSS2:ERG | RT-PCR | RNA | Urine | USA | 56–71 | Cohort | 48 (45) |