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Total recovery. Total recovery at 60 min of TVP and two TVP metabolites, DM-4103 and DM-4107, expressed as a percentage of dose, in (A) liver, (B) outflow perfusate, and (C) bile in isolated perfused livers from WT and PCK rats. Significant differences between WT and PCK per sample type were assessed for each of the three chemical species. Data are presented as mean ± S.D. (n = 6 for WT; n = 5 for PCK). *P < 0.05, PCK vs. WT.
