Skip to main content
. 2018 Dec 31;116(3):798–803. doi: 10.1073/pnas.1819107116

Fig. 7.

Fig. 7.

Putative role of Mcm10 in fork regression repair. (A) Unperturbed replication fork. Mcm10 is located at the top of the replisome and binds the forked DNA nexus, preventing fork regression by DNA translocases, such as SMARCAL1. (B, Left) Perturbed fork with a leading strand lesion. CMG and Pol ε-PCNA uncouple on encountering a leading strand lesion, and CMG may dissociate after an unspecified distance of continued unwinding and lagging strand synthesis. (B, Right) SMARCAL1 can perform fork regression for lesion repair or error-free lesion bypass.